Publications
Peer Reviewed Journals


          • Nath, N.K.; Yasuda, N.; Rabeh, W.M.; Chandra Sahoo, S.; Naumov, P. Structural Elucidation of the Neuraminidase Inhibitor Zanamivir (Relenza): Creeping and Diffusion for Polymorph Separation. (2013) Cryst Growth Des 14 (2): 770–774

 

          • Naumov P.; Yasuda, N.; Rabeh W.M.; Bernstein, J. The elusive crystal structure of the neuraminidase inhibitor Tamiflu (oseltamivir phosphate): molecular details of action. (2013) Chem Commun 49(19):1948-50.

 

          • Ahner, A.; Gong, X.; Schmidt, BZ.; Peters, K.W.; Rabeh, W.M.; Thibodeau, P.H.; Lukacs, G.L.; Frizzell, R.A. Small heat shock proteins target mutant CFTR for degradation via a SUMO-dependent pathway. (2013) Mol Biol Cell 24(2):74-84.

 

          • Rabeh, W.R.; Bossard, F.; Xu, H.; Okiyoneda, T.; Bagdany, M.; Liu, Y.; Mulvihill, C.M.; Du, K.; Di Bernardo, S.; Konermann, L.; Roldan, A.; Lukacs, G.L. Correction of both NBD1 energetics and domain interface is required to restore ∆F508 CFTR folding and function. (2012) Cell; 148(1-2): 150-63. (highlight: Featured on the cover page of Science-Business eXchange).

 

          • Colas, J.; Faure, G.; Saussereau, E.; Trudel, S.; Rabeh, W.M.; Bitam, S.; Guerrera, I.C.; Fritsch, J.; Sermet-Gaudelus, I.; Davezac, N.; Brouillard, F.; Lukacs, G.L.; Herrmann, H.; Ollero, M. and Edelman, A. Disruption of cytokeratin-8 interaction with F508del-CFTR corrects its functional defect. (2012) Hum. Mol. Genet; 21(3): 623-34.

 

          • Wyatt, E.; Wu, R.; Rabeh, W.; Park, H.W.; Ghanefar, M. and Ardehali, H. Regulation and Cytoprotective Role of Hexokinase III. (2010) PLoS One. 5(11): e13823

 

          • Okiyoneda, T.; Barrière, H.; Bagdány, M.; Rabeh, W.M.; Du, K.; Höhfeld, J.; Young, J.C. and Lukacs, G.L. Peripheral Protein Quality Control Removes Unfolded CFTR from the Plasma Membrane. (2010) Science. 329: 805-10.

 

          • Tai, C.H., Rabeh, W.M., Guan, R., Schnackerz, K.D. and Cook, P.F. Role of Histidine-152 in cofactor orientation in the PLP-dependent O-acetylserine sulfhydrylase reaction. (2008) Arch Biochem Biophys. 472, 115-25

 

          • Tai, C.H., Rabeh, W.M., Guan, R., Schnackerz, K.D. and Cook, P.F. Effect of mutation of lysine-120, located at the entry to the active site of O-acetylserine sulfhydrylase-A from Salmonella typhimurium. (2008) Biochim Biophys Acta. 1784, 629-37.

 

          • Rabeh, W.M.*, Tempel, W.*, Bogan, K.L., Belenky, P., Wojcik, M., Seidle, H.F., Nedyalkova, L., Yang, T., Sauve,A.A., Park, H.W. and Brenner,C. Nicotinamide Riboside Kinase Structures Reveal New Pathways to NAD+. (2007) PLoS Biol. 5(10): e263 *Co-first Authors

 

          • Hong, B.S., Senisterra, G., Rabeh, W.M., Vedadi, M., Leonardi, R., Zhang, Y.M., Rock, C.O., Jackowski, S. and Park, H.W. Crystal Structures of Human Pantothenate Kinases: Insights into Allosteric Regulation and Mutations linked to Neurodegeneration Disorder. (2007) J. Bio. Chem. 282, 27984-93

 

          • Dong A, Xu X, Edwards AM, Chang C, Chruszcz M, Cuff M, …. eta…Rabeh W, Shen L, Shen Y, Sukumard D, Tempel W, Tong Y, Tresagues L, Vedadi M, Walker JR, Weigelt J, Welin M, Wu H, Xiao T, Zeng H, Zhu H. In situ proteolysis for protein crystallization and structure determination. (2007) Nat. Methods. 4, 1019-21.

 

          • Rabeh, W.M.*, Chattopadhyay, A.*, Meier, M., Ivaninskii, S., Burkhard , P., Speroni, F.*, Campanini, B., Bettati,  S., Mozzarelli, A., Li, L. and Cook, P.F. Structure, Mechanism, and Conformational Dynamics of O-Acetylserine Sulfhydrylase from Salmonella typhimurium: Comparison of A and B Isozymes. (2007) Biochemistry 46, 8315-30 *Co-first Authors.

 

          • Rabeh, W. M., Mather, T. and Cook, P. F. A Three-Dimensional Homology Model of the O-Acetylserine Sulfhydrylase-B from Salmonella typhimurium.  (2006) Protein Pept Lett. 13, 7-13

 

          • Rabeh, W. M., Alguindigue, S. S. and Cook, P. F. Mechanism of the Addition Half of the O-Acetylserine Sulfhydrylase-A Reaction. (2005) Biochemistry 44, 5541-50.

 

          • Rabeh, W. M., and Cook, P. F. Structure and Mechanism of O-Acetylserine Sulfhydrylase. (2004) J. Bio. Chem. 279, 26803-26806

Invited Talks


            • Rabeh, W.M.; Joel Bernstein. Crystal Growth to Foster Inquiry−Based Learning: First Year Science Laboratory. 23rd International Union of Crystallography (IUCr) Congress. Aug. 5-12, 2014. Montreal, QC, Canada.

 

            • Rabeh, W.R.; Edwards, A.M. Human Hexokinase 2: a Key Enzyme and Promoter of Tumor Growth. ARC’13: Qatar Foundation Annual Research Conference. Nov 23-25, 2013. Doha, Qatar.

 

            • Rabeh, W.R. and Lukacs, G.L. Cystic Fibrosis Disease Mechanism: Recovery of the Misfolded CFTR Channel. Drug Discovery & Therapy World Congress: Jun 3-6, 2013. Boston, USA

 

            • Rabeh, W.R.; Bossard,F.; Xu, H.; Okiyoneda, T.; Bagdany, M.; Mulvihill, C.M.; Du, K.;Di Bernardo, S.; Liu, Y.; Konermann, L.; Roldan, A. and Lukacs, G.L. Correction of the Misfolded Cystic Fibrosis Transmembrane Conductance Regulator Channel is a Two-Step Process. 5th International Conference on Drug Discovery & Therapy: Feb. 18-21, 2013. Dubai, UAE

 

            • Rabeh, W.R.; Bossard,F.; Xu, H.; Okiyoneda, T.; Bagdany, M.; Mulvihill, C.M.; Du, K.;Di Bernardo, S.; Liu, Y.; Konermann, L.; Roldan, A. and Lukacs, G.L. Correction of Both NBD1 Energetics and Domain Interface is Required to Restore ΔF508 CFTR Folding and Function. 35th European Cystic Fibrosis Conference: Jun. 6-9, 2012, Dublin, Ireland.P.54 (Oral presentations).

 

            • Rabeh, W.M. Protein Science in drug discovery and design. 1st Material Science Symposium: Mar. 8, 2012, Abu Dhabi, the United Arab Emirates

 

            • Rabeh, W.M., Bossard, F., Di Bernardo, S., Okiyoneda, T., Liu, Y., Mulvihill, C.M., Du, K., Xu, H., Konermann, L., Lukacs, G.L. Conformational stabilization of the NBD1 is necessary, but not sufficient for CFTR biogenesis. The 24nd Annual North American Cystic Fibrosis Conference: Oct 21-23, 2010, Baltimore, MD, United States. Pediatric Pulmonology 2010. P.220

Conference Presentations


              • Nawaz, M.H.; Rabeh, W.M.; How to Cure Cancer with a Pill? A Structure-Based Drug Design Study on Human Hexokinase 2 targeting different Tumor types. ARC’14: Qatar Foundation Annual Research Conference. Nov. 18-19, 2014. Doha, Qatar.

 

              • Nawaz, M.H.; Rabeh, W.M. The Mitochondrial Dissociation Effect on the Human Hexokinase 2 and its role in Tumor Progression. Enzyme mechanisms by biological systems, EMBO conference. Jun. 1-4, 2014. Manchester, UK.

 

              • Rabeh, W.R.; Bossard,F.; Xu, H.; Okiyoneda, T.; Bagdany, M.; Mulvihill, C.M.; Du, K.;Di Bernardo, S.; Liu, Y.; Konermann, L.; Roldan, A. and Lukacs, G.L. Recovery of the Genetic Mutation of CFTR Channel and the Cystic Fibrosis Disease Mechanism. ARC’13: Qatar Foundation Annual Research Conference. Nov 23-25, 2013. Doha, Qatar.

 

              • Okiyoneda, T.; Guido, V.; Xu, H.; Roldan, A.; Bagdany, M.; Rabeh, W.M.; Lukacs, G.L. Pharmaco- and chemical-chaperone combination synergistically rescues the delF508-CFTR coupled domain-folding defect in cystic fibrosis. Molecular Chaperones & Stress Responses. May 1- 5, 2012, Cold Spring Harbor, NY, USA.

 

              • Rabeh, W.M., Bossard, F., Di Bernardo, S., Okiyoneda, T., Liu, Y., Mulvihill, C.M., Du, K., Xu, H., Konermann, L., Lukacs, G.L. Linking the deletion of F508 imposed localized NBD1 folding defect to CFTR cooperative misassembly in cystic fibrosis. 1st Arab-American Frontiers Symposium: Oct. 17-19, 2011, Kuwait City, Kuwait.

 

              • Rabeh, W.M.; Zhu, H.; Nedyalkova, L.; Tempel,  W.; Vedadi, M.; Arrowsmith,  C.H. and Edwards, A.M. The Crystal Structure of Human Hexokinase 2: a Key Enzyme and Promoter of Tumor Growth. Changing Landscape of the Cancer Genome: June 20 - 25, 2011, Boston, MA, USA

 

              • Rabeh, W.M. et al. (2010) Conformational stabilization of the NBD1 is necessary, but not sufficient for CFTR biogenesis. Ped. Pulm. Suppl. 33, 220

 

              • Okiyoneda, T. ; Apaja, P.M.; Barriere, H.; Bagdany, M.; Rabeh, W.M.; Du, K.; Hohfeld, J.; Young,  J.C.; Lukacs, G.L. Protein quality control mechanism responsible for triage decision of unfolded CFTR at plasma membrane. Gordon Research Conference (Lysosomes & endocytosis): Jun 20-25, 2010. Andover, NH, USA.

 

              • Gong, X., Ahner, A., Schmidt, B., Rabeh, W.M, Lukacs, G., Thibodeau, P., Frizzell, R.A. Preferential Sumoylation of ∆F508 CFTR and NBD1 Leads to Protein Degradation. The 33rd European Cystic Fibrosis Society Conference: Jun 16-19, 2010, Valencia, Spain.

 

              • Rabeh, W.M., Di Bernardo, S., Xu, H., Mulvihill, C.M., Du, K. and Lukacs, G.L. CFTR Folding in Vitro and in Vivo: Implication of Cooperative Domain Assembly. 2010 ECFS Basic Science Conference: April 7-10, 2010, Carcavelos, Portugal. European Cystic Fibrosis Society

 

              • Okiyoneda, T. ; Barriere, H.; Bagdany, M.; Rabeh, W.M.; Young,  J.C.; Lukacs, G.L. Quality control machinery responsible for ubiquitination and elimination of misfolded CFTR from the cell surface. Annual GRASP/MSBR Symposium: Nov 23-24, 2009, Montreal, QC, Canada.

 

              • Okiyoneda, T. ; Barriere, H.; Bagdany, M.; Rabeh, W.M.; Young,  J.C.; Lukacs, G.L.  Quality control machinery responsible for ubiquitination and elimination of misfolded CFTR from the cell surface. Cell Stress Society International (CSSI) The 4th International Congress on Stress Response in Biology and Medicine, The 4th Annual Meeting of The Biomedical Society for Stress Response (BSSR): Oct 6-9, 2009, Sapporo, Japan.

 

              • Rabeh, W.M., Mulvihill, C.M., Di Bernardo, S.,Bagdany, M., Du, K. and Lukacs, G.L. The Biophysical Characteristics defect of ∆F508 on the nucleotide binding domain 1 of the cystic fibrosis transmembrane conductance regulator. The 1st Annual GRASP Symposium: Nov 24, 2008, Montreal, Quebec, Canada. Groupe de Recherche Axésur la Structure des Protéines.

 

              • Rabeh, W.M., Mulvihill, C.M., Di Bernardo, S., Bagdany, M., Du, K. and Lukacs, G.L. Characterization of Wild-Type and ∆F508-NBD1 with a Single Solubilization Mutation. The 22nd Annual North American Cystic Fibrosis Conference: Oct 23-25, 2008, Orlando, FL, United States. Pediatric Pulmonology 2008, p 205.

 

              • Rabeh, W.M. and Cook, P.F. Mechanism of the second-half of the O-Acetylserine Sulfhydrylase-A reaction. The 19th Enzyme Mechanisms Conference: Jan 5-9, 2005 Pacific Grove, CA, United States.

 

              • Rabeh, W.M. and Paul, F.C. Insights into the kinetic mechanism of Malic Enzyme from Ascaris suum. The 90th  Annual Technical Meeting: Nov 2, 2001 Oklahoma City, OK, United States. Oklahoma Academy of Science.

Protein Crystal Structures